Singulair vs Zyrtec Comparison - Drugs.com (2024)

View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
SingulairZyrtec
View side-by-side comparisons of medication uses, ratings, cost, side effects and interactions.
Singulair(montelukast)Zyrtec(cetirizine)
Prescription only

Singulair is used in addition to other treatments for the maintenance treatment of asthma. It does not relieve acute attacks and may cause neuropsychiatric effects in a small number of people...View more

Prescription and OTC

Zyrtec is an antihistamine that effectively treats allergic reactions such as hay fever or skin reactions caused by insect bites. Although drowsiness with Zyrtec is uncommon, Zyrtec is more likely...View more

More aboutSingulair(montelukast)More aboutZyrtec(cetirizine)
Ratings & Reviews

Singulair has an average rating of6.5 out of 10 from a total of218 ratings on Drugs.com.53% of reviewers reported a positive effect, while 31% reported a negative effect.

Zyrtec has an average rating of5.8 out of 10 from a total of195 ratings on Drugs.com.43% of reviewers reported a positive effect, while 35% reported a negative effect.

View all 218 reviews

View all 195 reviews

Drug Class
Side Effects

See also: Singulair side effects in more detail.

See also: Zyrtec side effects in more detail.

Generic Availability

Lower cost generic approved

Lower cost generic approved
Pricing and Coupons* Prices are without insurance
Quantity30 tablet
Dosage10 mg
Per Unit*$9.53
Cost*$285.89

View all Singulair prices

Quantity14 tablet
Dosage10 mg
Per Unit*$1.59
Cost*$22.26

View all Zyrtec prices

Get free Discount Card

Get free Discount Card

Dosage Forms Available
  • Oral granule
  • Oral tablet
  • Oral tablet, chewable
  • Oral capsule
  • Oral syrup
  • Oral tablet
  • Oral tablet, chewable
  • Oral tablet, dispersible
Brand Names

N/A

Other cetirizine brands include: All Day Allergy, All Day Allergy Children's, Aller-Tec, Aller-Tec Children's, Alleroff, Children's Allergy Relief, Equate Allergy Relief, PediaCare Children's 24-Hour Allergy, Quzyttir, Zyrtec HivesView more
Half LifeThe half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

5.5 hours

10.6 hours

CSA Schedule **View glossary of terms

N

Not a controlled drug

Is not subject to the Controlled Substances Act.

N

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

B

Category BNo proven risk in humans

See the full pregnancy warnings document.

B

Category BNo proven risk in humans

See the full pregnancy warnings document.

Drug Interactions

A total of 110 drugs are known to interact with Singulair:

  • 110 moderate drug interactions (337 brand and generic names)

A total of 257 drugs are known to interact with Zyrtec:

  • 2 major drug interactions (4 brand and generic names)
  • 253 moderate drug interactions (1077 brand and generic names)
  • 2 minor drug interactions (41 brand and generic names)
Alcohol/Food/Lifestyle Interactions

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

  • Alcohol can increase the nervous system side effects of cetirizine such as dizziness, drowsiness...View more

Disease Interactions
First Approval Date

February 20, 1998

N/A

WADA ClassView World Anti-Doping Agency classifications.

N/A

N/A

More Information
Patient resources
Professional Resources
Related Treatment Guide

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circ*mstances.

Medical Disclaimer

Singulair vs Zyrtec Comparison - Drugs.com (2024)
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